Mesenchymal stromal cell-derived membrane particles as a new therapeutic strategy for inflammatory diseases

Project summary

Mesenchymal stromal cells (MSC) are a promising therapy for degenerative, inflammatory and autoimmune diseases due to their multipotent differentiation capacity, secretion of trophic factors, and immunomodulatory properties. However, MSC therapy comes with practical difficulties associated with the use of living cells. We aim to develop cell-free immune therapy based on the generation of small particles from the membranes of MSC. These particles contain the membrane bound proteins of MSC, several of which have an immunomodulatory function.