Understanding early processes in osteoarthritis: Paving the way for novel drugs (HypOA).

Project summary

Osteoarthritis is a disease of the locomotor system characterised by degeneration of cartilage and underlying bone. Recent publications have indicated changes in the properties of cartilage cells occur (chondrocytes) before the tissue is damaged. We hypothesise that intervention in the pathway of these early changes in chondrocytes will prevent progression of osteoarthritis into a chronic disabling disease. With this partnership Erasmus MC and Galapagos will generate more knowledge on the changes that chondrocytes undergo during osteoarthritis and develop laboratory models to help develop new treatments.

Osteoarthritis is a painful and disabling disease and there currently is no cure. It has been identified as a serious disease determining morbidity and mortality in elderly.

The number of Dutch osteoarthritis patients will almost double to 2.3 million patients in 2040. Without effective intervention in this disease the central mission of LSH to add at least five years in good health to the lives of all Dutch citizens by 2040, is unachievable. To develop an effective pharmacological treatment, we need to intervene in key pathways early in the disease. To obtain more insight in molecular processes that initiate these changes and in the progression of the phenotypical changes we will develop models to study whether and how blood vessels and inflammation (both occurring in early stages of osteoarthritis) stimulate changes in chondrocyte behaviour. Finally, we will channel these results into creating a lab based high throughput model to enable studies on molecular processes and to discover targets for the development of drugs for osteoarthritis. With globally >300 million patients and no available cure it can be foreseen that an effective intervention created using our model has the potential for rapid penetration in the market.