Restoring T-cell immunity in aggressive breast cancer: Serpins as actionable targets

Project summary

Patients with aggressive breast cancer (BC) do not benefit from current therapies. My preliminary data demonstrate that an under-recognized family of proteins, termed Serpins, limit immune cells from reaching and/or eradicating BC. I will interrogate Serpins for anti-immune mechanisms and explore enzymeneutralizing strategies to restore therapeutic responses of aggressive BC.