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Hijack protein degradation to overcome immune-inhibition in cancer


Client :
Liquid Themes

Hijack protein degradation to overcome immune-inhibition in cancer

Project summary

In this project, we pioneer a novel type of therapy that will boost the immune system´s ability to fight cancer. Normally, T-killer cells are the most potent immune cells in this regard, as they can deplete cancer cells after recognition of specific surface-exposed molecules. However, through the accumulation of mutations cancer cells frequently gain the potential to prevent T-killer cell activation by generating an inhibitory microenvironment in surrounding tissues. Here, we propose to use a class of small molecules called “proteolysis targeting chimeras” (or PROTACs) to block immune inhibition for improved cancer eradication by T-killer cells.

More detailed information

Principal Investigator:

prof. dr. C. Schliehe

Role Erasmus MC:

Principal Investigator

Department:

Immunology

Project website:

Funding Agency: