Hijack protein degradation to overcome immune-inhibition in cancer
Client :
Liquid Themes
Hijack protein degradation to overcome immune-inhibition in cancer
Project summary
In this project, we pioneer a novel type of therapy that will boost the immune system´s ability to fight cancer. Normally, T-killer cells are the most potent immune cells in this regard, as they can deplete cancer cells after recognition of specific surface-exposed molecules. However, through the accumulation of mutations cancer cells frequently gain the potential to prevent T-killer cell activation by generating an inhibitory microenvironment in surrounding tissues. Here, we propose to use a class of small molecules called “proteolysis targeting chimeras” (or PROTACs) to block immune inhibition for improved cancer eradication by T-killer cells.
More detailed information
Principal Investigator:
prof. dr. C. Schliehe
Role Erasmus MC:
Principal Investigator
Department:
Immunology
Project website:
Funding Agency: