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Identifying the tumor stroma as a key player in resistance to internal radiation treatment


Client :
Liquid Themes

Identifying the tumor stroma as a key player in resistance to internal radiation treatment

Project summary

Tumors do not only consist of cancer cells, but also of tumor stroma, containing various cell types and extracellular matrix components. With the aim of improving therapy responses, research often focusses only on the tumor cells; meaning that the potential role of the stroma is neglected. Here, the focus is on how the most abundant stromal cell type, i.e. cancer-associated fibroblasts, affects the cancer cells’ sensitivity towards internal radiation. Gaining these insights will both boost the development of novel strategies for improved therapeutic responses, and open a new research area focused on the role of the tumor stroma in radiosensitivity.

More detailed information

Principal Investigator:

dr. M.J. Klomp

Role Erasmus MC:

Principal Investigator

Department:

Rad&NuGe O. Algemeen

Project website:

Funding Agency: